Management of HS with spironolactone reduces lesion count, HS-PGA score, and pain. Lower doses appear to be effective and may be an appropriate option for patients with tolerability concerns. Antiandrogen therapy with spironolactone for the treatment of hidradenitis suppurativa
Spironolactone is a potassium-sparing medication used as a diuretic medication for heart failure, liver disease and high blood pressure. However, it has also been found useful for hirsutism, acne and seborrhoea because it has anti-androgenic properties. Spironolactone mainly works by blocking androgen receptors.
Spironolactone (Aldactone) is a type of anti-androgen that’s been used for 30 years to treat hormonal acne and excessive body hair. People transitioning may take it to reduce masculine traits….
Spironolactone has two roles: it’s an aldosterone antagonist and an anti androgen. It blocks the androgen receptor which is the cytoplasmic receptor for dihydrotesterone (DHT) and it also inhibitors androgen biosynthesis.
Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. It is also used in the treatment of high blood pressure, low blood potassium that does not improve with supplementation, early puberty in boys, acne and excessive hair growth in women, and as a part of …
Besides being a potassium-sparing diuretic, Spironolactone acts as an anti androgen that works in two ways. First of all it slows down the production of androgens in the adrenal glands and ovaries. Secondly it blocks the action of androgens in part by preventing dihydrotestosterone from binding to its androgenetic receptor. Spironolactone Dosage . Spironolactone is available from Medical …
As for its indications in hair, Spironolactone is known to be a well tolerated and effective antiandrogen. It is sometimes used to treat female pattern baldness and excessive facial hair (hirsutism) in women and occasionally men use it as an antiandrogen under close supervision by their doctors.
Spironolactone is just like the pseudo-steroid drugs in the pill. In fact, spironolactone is very similar to the progestin drospirenone used in Yasmin and Yaz Pills. Spironolactone fits (blocks) your testosterone receptor, which is why it’s used, but unfortunately, it also disrupts ovulation, estrogen metabolism and adrenal function.
Spironolactone (“Spiro”) is a potassium-sparing diuretic and steroid drug frequently prescribed in the US to assigned-male-at-birth (AMAB) trans women as part of their HRT.
Some anti-androgens directly block the androgen receptors: When the androgens cannot bind to their receptors, they cannot function properly. Other anti-androgens work by reducing the production of androgens in the body. Lowering the level of androgens will automatically reduce the effects of excessive androgen.